A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension, with a focus on Mendelian randomisation.
Year: 2025
Type: article
Abstract: There are two issues with using existing data from general-population biobanks to study PAH: low power and non-random misclassification. Relative to gold standard data, this results in false-positive and false-negative findings. https://bit.ly/4nksm6c
Source: Apollo (University of Cambridge)
DOI: 10.17863/cam.121079
Authors: Woolf, Benjamin, De Bie, Eckart, McLaughlin, Vallerie, Gräf, Stefan, Toshner, Mark, Wilkins, Martin R, Rhodes, Christopher J, Burgess, Stephen
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7079978899
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