Work

A Review on Role of HSP70 in Treatment of Cancer

Year: 2025

Type: article

Abstract: HSP 70 (Heat shock proteins) are an old defense mechanism found in all species. By facilitating the correct folding and refolding of misfolded proteins and aiding in the removal of aged and damaged cells, these proteins function as molecular chaperons Hsp100, Hsp90, Hsp70, Hsp40 and tiny heat shock proteins are example of heat shock proteins. Heat shock protein 70 interact with a broad range of molecules, including unfolded, natively folded, and aggregated proteins, through its substrate binding domains and offers cytoprotection against a variety of cellular stressors. High levels of Hsp70 expression enable cells to endure fatal wounds under pathological circumstances. Increased Hsp70 inhibits apoptosis by interfering with many apoptotic signaling pathways.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17054316

Author: M. Durga Bhavani*, J. N. Suresh Kumar, B. Venkata Sainadh, S. Sanni, P. Vinod, T. Pallavi, E. Lakshmi Sravani.

Language: English

Topic: Heat shock proteins research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7079983051

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