ためこみ症における島皮質と下前頭回および上側頭回の安静時機能的結合性低下
Year: 2025
Type: dissertation
Study design: Observational Study
Abstract: Background: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks.However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear.Methods: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study.We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels.Results: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs.There was no correlation between these connectivities and HD symptoms.Conclusions: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies.These findings provide new insight into the neurobiological basis of HD.
Author: 加藤, 研太
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Awards: Abnormal cortical gyrification and executive function involvement in hoarding disorder., Identification of endophenotype in tic-related obsessive-compulsive disorder, 注意欠如/多動性障害の反応抑制障害の基盤となる安静時の大域的脳ネットワークの検索, Investigation of the brain structural abnormalities in Hoarding Disorder by using diffusionte
OpenAlex ID: W7080047267