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Enhanced phototherapeutic effects of laser-irradiated Ag NPsdecorated TiO2 Nanotubes in colon cancer cells

Year: 2025

Type: article

Abstract: Silver nanoparticles (Ag NPs) successfully decorated on titanium dioxide (TiO2 ) nanotubes (NTs). The effect of Ag NPs decorated TiO2 NTs on colon cancer cells (SW480 cells) is investigated with/without laser exposure at 532 and 808 nm in different times and various concentrations (15.6, 31.25, 62.5, 125, 250, 500μg/ mL). The aims to determine different doses and effective concentrations of Ag NPs-decorated TiO2 for low-energy laser treatment. Colon cancer (SW480) cells y was conducted for the green laser (=532 nm, power=300 mW) and NIR laser rays (= 808 nm, power=150 mw). The untreated cells (control group) maintain a high level of viability across all concentrations of Ag NPs decorated TiO2 NTs. The results indicate that the treatment with Ag NPs-decorated TiO2 NTs and green laser significantly reduced the cancer cell viability in a dose-dependent manner. This study demonstrates the potential of Ag NPs-decorated TiO2 NTs as a novel nanomaterial for photothermal therapy of colon cancer. This approach has several advantages over conventional therapies, including minimal invasiveness, and reduced side effects.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17097332

Authors: Maher, I. Al-Shemri, S. Z., Mortazavi, M. R., Khanlary, Rana, A. Ghaleb, A., Reyhani

Institutions: Imam Khomeini International University, Amirkabir University of Technology, University of Babylon

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7081083333

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