The Protective Effects of Vernonia Amygdalina, Ocimum Gratissimum and Talinum Triangulare on Cardiac Toxicity in Dichlorvos-Treated Wistar Rats
Year: 2025
Type: article
Abstract: This research assessed the efficacy of Vernonia amygdalina, Ocimum gratissimum, and Talinum triangulare extracts in ameliorating dichlorvos (DDVP)-induced cardiotoxicity. Fifty adult male Wistar rats (272 g) were distributed into ten groups (n=5), including negative and positive controls (saline and 8.0 mg/kg DDVP, respectively), and treatment groups co-administered DDVP with either plant extracts (200 or 400 mg/kg) or vitamin C (20 or 40 mg/kg) for 28 days. DDVP intoxication significantly increased (p < 0.05) cardiac injury biomarkers (LDH and CK). However, all three plant extracts significantly attenuated this rise, demonstrating a dose-dependent protective effect. Histological analysis of cardiac tissue confirmed the biochemical evidence of cardioprotection. These findings indicate that the tested botanicals hold promise as therapeutic agents against pesticide-induced myocardial damage
Authors: Ambrose, Okunima, Anakwe, Chukwuma Samuel, E.M, Aisuodionoe, Chukwudi, Okonkwo Browne, Akinola, Aduloju Richard
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7081580098
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