Development of a Clinical-immunological Model for Predicting Unfavorable Myocardial Remodeling in Children With Vsd After Transcatheter Intervention
Year: 2025
Type: article
Abstract: This study examines immune-related predictors of myocardial remodeling in children following transcatheter closure of ventricular septal defect (VSD). Two hundred pediatric patients were observed at baseline, 1 month, and 12 months after the intervention. Assessments included echocardiography, cardiac MRI, cytokine and immunoglobulin profiles, and systemic inflammatory markers. Children with adverse remodeling showed increased IL-6, TNF-α, and C-reactive protein, together with reduced IL-10 and IgG levels. Imaging revealed ventricular enlargement and lower ejection fraction. A combined clinical-immunological risk model was established, demonstrating predictive accuracy of 86% sensitivity and 83% specificity. These findings highlight immune imbalance as a key determinant.
Authors: Yusubov, Alisher, Umarov, Baxtiyorjon, Mullabayeva, Guzal
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7081623334
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