A Comprehensive and Systemic Review on the Development and Validation of Different Analytical Methods for the Estimation of Cyclobenzaprine
Year: 2025
Type: article
Abstract: Cyclobenzaprine, a muscle relaxant commonly prescribed for muscle spasms, has been the subject of various analytical methods for its determination in pharmaceutical formulations and biological samples. This review critically evaluates the existing analytical techniques, focusing on UV, High-performance liquid chromatography (HPLC), Mass spectrometry (MS), and Liquid chromatography-tandem mass spectrometry (LC-MS/MS). The methods are assessed based on their sensitivity, specificity, accuracy, and applicability in different matrices. Recent advancements highlight the development of robust methodologies that comply with ICH guidelines, ensuring reliable quantification of cyclobenzaprine and its degradation products.
Author: Kajal Vable*, Yaksh Gandhi, Khushi Prajapati, Himani Vaghasiya, Dr. Mitali Dalwadi, Dr. Chainesh Shah, Dr. Priyanka Patil, Dr. Umesh Upadhyay, Khushbu Shah
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7081673057
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