Evaluation of Safety and Efficacy of Cannaquic Oil In Comparison With Diclofenac Oil For The Management Of Osteoarthritis – A Double-Blind, Randomized Controlled Clinical Study
Year: 2025
Type: article
Abstract: Background:Osteoarthritis (OA) is the most prevalent type of arthritis in the globe. Considerable adverse effects of existing therapeutic agents have widened the scope of development of a new, safer and effective medicine for osteoarthritis. The present study aimed to evaluate the safety and efficacy of cannaquic oil in comparison with diclofenac oil for the management of osteoarthritis. Methods:A randomized, double-blind, controlled trial was conducted to compare the efficacy and safety of Cannaquic and diclofenac in patients with knee osteoarthritis. Participants were randomly assigned to receive either Cannaquic oil or diclofenac oil for 30 days. clinical assessment and laboratory findings were compared between day 0 and day 30 and post study follow up was analyzed between day 0 and day 60. Results:A total of 80 patients were enrolled in the study. Cannaquic oil reduces pain, stiffness, and inflammation, as seen in the decreased VAS, WOMAC, ESR, IL-1, IL-6, and TNF levels during the study period. No significant changes (p > 0.05) were observed in hematological, liver, renal, and blood glucose parameters, indicating safety. A total of 41 adverse drug reactions were reported, with gastrointestinal disturbances being the most common (34.15%). When comparing cannaquic oil and diclofenac oil, Cannaquic oil shows long term benefits in post study follow up. Conclusion:The results demonstrated that the cannaquic oil was safe and efficacious for long time use for pain relief compared to diclofenac oil for OA.
Source: Journal of Carcinogenesis
Authors: Satish kumar Rajappan Chandra, Meenakshi Sundari, Bhuvaneshwaran Mothishwaran, Kamala-Kannan Seralathan, Shivaprasad Hudeda
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W7081913643
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