Work

Management considerations for a patient with Isaacs syndrome versus cramp fasciculation syndrome on dantrolene: A case report

Year: 2025

Type: article

Abstract: Isaacs syndrome (IS) is a rare condition that causes muscle stiffness, myokymia, and muscle twitching which may impact the surgical field, patient respiratory function, and patient comfort. Cramp fasciculation syndrome (CSF) presents with a less severe clinical picture but may impact patient lifestyle. We present a report of a successful total intravenous anesthetic using rocuronium and sugammadex for a patient with IS/CFS undergoing inguinal hernia repair. The consideration for TIVA was influenced by the patient's chronic use of dantrolene therapy. The patient did not receive preemptive administration of dantrolene, but intravenous dantrolene was immediately available if the patient had symptomatic muscle stiffness or myokymia.

Source: JCA advances.

DOI: 10.1016/j.jcadva.2025.100162

Authors: Muhammad Salim, Julie M. Marshall

Institution: University of Missouri

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,200