Work

The Effect and Mechanism of Gut Microbiota Changes in Spleen Deficiency Environment on Alzheimer’s Disease Rats

Year: 2025

Type: article

Abstract: An AD model was established in male Sprague–Dawley rats via bilateral intraventricular injection of amyloid β protein (Aβ)1–42, while a spleen deficiency model was induced by subcutaneous injection of reserpine. The rats were divided into four groups: normal control (NC), AD model (AD), spleen deficiency model (SD), and combined AD with spleen deficiency model (AD+SD). Cognitive behavior and AD-related pathology were evaluated using the Morris water maze test and immunohistochemistry. Changes in the gut microbiota were assessed via 16S rRNA sequencing.

Source: Biomedical Journal of Scientific & Technical Research

DOI: 10.26717/bjstr.2025.63.009852

Author: Ying Juan Huang

Institutions: Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7081976256