Comparative Effectiveness Trial of Tobacco Cessation Treatments among Cancer Patients who Smoke
Year: 2025
Type: preprint
Abstract: This pilot comparative effectiveness trial will compare two active smoking cessation treatments in terms of effectiveness among adult patients diagnosed with cancer within the past 3 years, and explore equitability of treatment effects across patient subpopulations, and efficiency in terms of cost-effectiveness. An enhanced treatment comprising 12 weeks of varenicline treatment and 7 smoking cessation coaching calls with a cancer focus will be compared against an active comparator modeled after standard quitline treatments (2 weeks of nicotine patch therapy with 3 phone coaching calls). Participants (N = 52) were recruited for this 7-month study to generate estimates of the effects, acceptability, costs, and equitability of enhanced treatment (vs. standard treatment), with the primary outcome being abstinence from smoking 12 and 26 weeks after trying to quit. Qualitative interviews will be conducted with adult patients (N < 32) with a history of cancer to inform study methods and smoking cessation counseling tailored to cancer care.
Authors: Baker, Timothy, McCarthy, Danielle E, Kaye, Jesse T., Fiore, Michael C.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6906626040