A comprehensive review: Breast cancer and the role of natural products in its treatment via in silico approach
Year: 2025
Type: article
Abstract: Breast cancer is the most frequent malignancy and a leading cause of cancer-related death among women, thus representing a global health challenge linked to its high heterogeneity. However, there has been major progress in breast cancer diagnosis and therapy, still it remains a heavy burden with high incidence and death rate majorly in females. This review provides a comprehensive exploration of breast cancer, mechanism pathways and treatment options and highlights the potency of significant alkaloids, flavonoids, and other natural compounds, emphasizing their potential as therapeutic agents. Moreover, the present study employs an approach focusing on computational methods including molecular docking, molecular dynamics simulation, and Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) to investigate the potential of natural products in breast cancer treatment. Furthermore, this review concludes by the discussion of recent studies which outlines the role of natural products via in silico approach for breast cancer treatment.
Authors: Shinde, Manasi A, Rangdal, Deepa N, Nalawade, Riya A, Sharma, Ranikumari S, Pardale, Shruti P, Tayade, Rajendra R., Bhatu, Minakshi N., Patil, Shubhangi P
Institution: Institute of Science, Nagpur
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7082159221
FWCI:
Cites:
Cited by:
Related to: