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Nano-delivery Systems for mRNA: A comprehensive review of lipid-based and polymer-based approaches

Year: 2025

Type: article

Abstract: Messenger RNA (mRNA) has emerged as a promising therapeutic tool for the treatment of various diseases, including cancer, infectious diseases, and genetic disorders. mRNA-based therapies offer several advantages over traditional gene therapy approaches, including temporary expression, adaptability, and improved safety profiles. The development of mRNA-based therapies has undergone significant advancements, with three distinct phases identified. Phase-I involved the discovery of mRNA, in vitro synthesis, and the development of nucleic acid delivery systems. Phase-II saw the clinical trials of mRNA vaccines for infectious diseases and cancer, while Phase-III is characterized by the emergency use authorization of mRNA-based vaccines for SARS-CoV-2. However, the delivery of mRNA remains a significant challenge due to its instability and difficulty in crossing cellular membranes. To overcome these challenges, various delivery systems have been developed, including lipid nanoparticles (LNPs), lipoplexes, and polymer-based nanoparticles.

Source: GSC Advanced Research and Reviews

DOI: 10.5281/zenodo.17164843

Authors: Turankar, Chetan C., Kubde, Jitendra A., Hatwar, Pooja R., Bakal, Ravindra L., Mahure, Lalit D.

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7082375977

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