Mast Cell Distribution and Its Correlation with Disease Severity in Leprosy: A Histopathological Study
Year: 2025
Type: article
Abstract: Background: Mast cells play a crucial role in inflammatory dermatoses. This study investigates mast cell distribution and its correlation with disease severity in leprosy. Methods: A retrospective observational study analyzed 46 leprosy cases and 28 controls. Mast cell counting was performed using toluidine blue staining and high-power microscopy. Results: Leprosy cases showed varying mast cell distributions: lepromatous leprosy (12-54 cells/10 HPF), tuberculoid leprosy (20-53 cells/10 HPF), borderline tuberculoid leprosy (22- 42 cells/10 HPF), and indeterminate leprosy (15-89 cells/10 HPF). Mast cell counts correlated with disease severity. Discussion: This study highlights the importance of mast cells in leprosy pathogenesis and suggests their potential role in disease severity. Regional variations in mast cell distribution were observed. Conclusion: Mast cell distribution analysis may serve as a diagnostic tool in leprosy, emphasizing the need for integrated clinical and histopathological approaches.
Source: Journal of Carcinogenesis
Authors: Sudha V B, Sanjay Sawant, Navyashree N, Sudarshan Reddy C
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W7082656438
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