COVID-19 and Subclinical Hypothyroidism as Dual Modulators of Myocardial Infarction Risk: A Clinical-Biochemical Perspective
Year: 2025
Type: article
Abstract: Background: Subclinical hypothyroidism (SCH) is a risk factor for cardiovascular disease (CVD), particularly myocardial infarction (MI), due to its association with dyslipidemia, inflammation, oxidative stress, and endothelial dysfunction.COVID-19 exacerbates these risks by disrupting thyroid function and the renin-angiotensin system (RAS).Methodology: This retrospective study included 90 MI patients (45 with and 45 without COVID-19).Thyroid function, lipid profiles, oxidative stress, and inflammatory markers were assessed.Cardiac severity was evaluated using ECG changes, levels of biochemicak markers like troponin I, CK-MB.Results: SCH patients had elevated TSH (6.2 vs. 4.8 mIU/L, p < 0.05), LDL (157.2 mg/dL), triglycerides (189.6 mg/dL), oxidative stress (MDA: 5.2 nmol/mL), and CRP (12.6 mg/L, p < 0.01).Cardiac injury markers and hospital stays were significantly worse in COVID-19 MI patients.Conclusion: SCH is an independent risk factor for MI, worsened by COVID-19.Routine thyroid screening in MI patients and further research on thyroid hormone therapy (THRT) are recommended.
Source: Kurdish Studies
Author: Muhammad Imran Aftab
Institution: University of Lahore
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7083181865
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