[18F]FDG PET/CT: EANM procedure guidelines for tumour imaging: version 3.0
Year: 2025
Type: article
Abstract: The purpose of these guidelines is to assist physicians in recommending, performing, interpreting and reporting the results of [ 18 F]FDG PET/CT for oncological imaging of adult and paediatric patients. PET is a quantitative imaging technique and therefore requires a common quality control (QC)/quality assurance (QA) procedure to maintain the accuracy and precision of quantitation. Repeatability and reproducibility are two essential requirements for any quantitative measurement and/or imaging biomarker. Repeatability relates to the uncertainty in obtaining the same result in the same patient when they are examined more than once on the same system. However, imaging biomarkers should also have adequate reproducibility, i.e. the ability to yield the same result in the same patient when that patient is examined on different systems and at different imaging sites. Adequate repeatability and reproducibility are essential for the clinical management of patients and the use of [ 18 F]FDG PET/CT within multicentre trials. A common standardised imaging procedure will help promote the appropriate use of [ 18 F]FDG PET/CT imaging and increase the value of publications and, therefore, their contribution to evidence-based medicine. Moreover, consistency in numerical values between platforms and imaging centres that acquire the data will potentially enhance the role of semi-quantitative and quantitative image interpretation. Precision and accuracy are additionally important as [ 18 F]FDG PET/CT is used to evaluate tumour response as well as for diagnosis, prognosis and staging. Therefore, both the previous and these new guidelines specifically aim to achieve standardised uptake value harmonisation in multicentre settings.
Source: The EANM Journal
Authors: Ronald Boellaard, Ken Herrmann, Sally F. Barrington, Iain Cranston, Felix M. Mottaghy, Corneline J. Hoekstra, Thomas Beyer, Lucy C. Pike, Antoon TM. Willemsen, Michael M. Graham, Josée M. Zijlstra, Fred Verzijlbergen, Bernd J. Krause, Albert J. Arends, Wolfgang A. Weber, Otto S. Hoekstra, Roberto C. Delgado Bolton, Giorgio Testanera, Sigrid Stroobants, Arturo Chiti, Francesco Giammarille, Christophe Deroose, Wim JG. Oyen
Institutions: University Medical Center Groningen, Amsterdam University Medical Centers, Amsterdam UMC Location Vrije Universiteit Amsterdam, German Cancer Research Center, Essen University Hospital, Deutsches Konsortium für Translationale Krebsforschung, King's College London, Portsmouth Hospitals NHS Trust, Maastricht University Medical Centre, Maastricht University, Universitätsklinikum Aachen, RWTH Aachen University, Jeroen Bosch Ziekenhuis, Medical University of Vienna, University of Iowa, Radboud University Nijmegen, Radboud University Medical Center, Universitätsmedizin Rostock, Catharina Ziekenhuis, TUM Klinikum, Technical University of Munich, Hospital San Pedro, Center for Biomedical Research of La Rioja, Servicio Cántabro de Salud, University of Antwerp, Antwerp University Hospital, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7083194196