Molecular and Immunological Mechanisms Underlying Inflammation during SARS-CoV-2 Infection
Year: 2025
Type: dissertation
Abstract: This thesis explores the immune mechanisms activated during SARS-CoV-2 infection across different disease severities through a comprehensive multi-omics approach. It specifically emphasizes the role of peripheral monocytes, investigating their programming during infection using bulk RNA-Sequencing. Additionally, the study delves into the development of antibodies in response to both infection and vaccination against the virus. Through single-cell RNA sequencing, it further deciphers the immune pathways activated in various immune cells within peripheral blood. This research provides valuable insights into the complex immune responses to SARS-CoV-2, connected to low interferon response, antigen presentation and highly pro-inflammatory state of severe COVID-19 patients.
Source: bonndoc (University of Bonn)
DOI: 10.48565/bonndoc-655
Author: Odainic, Alexandru
Institution: University of Bonn
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7083336853
Cites:
Cited by:
Related to: