Ten-year evaluation of HPV vaccine influence on non-vaccine-type-related cervical infections and precancers in Chinese females: follow-up from a randomized control trial
Year: 2025
Type: article
Abstract: The long-term influence of human papillomavirus (HPV) vaccination on untargeted types is poorly understood. The study assessed the influence of AS04-HPV-16/18 vaccination on non-vaccine-type infections and precancers through post-hoc analyses of a 10-year follow-up of China’s first HPV vaccine trial. In the clinical trial, females aged 18–25 years (N = 6051) were randomized 1:1 to receive either three doses of AS04-HPV-16/18 vaccine or control and followed for 6 years. After this trial, all participants were invited to an extended 10-year follow-up. The present post-hoc analyses evaluated cross-protection and type replacement based on virological and pathological endpoints. The AS04-HPV-16/18 vaccine provided 43.15% (95% CI: 20.17–59.96%) cross-protection against 6-month persistent infections related to HPV-31/33/45, while cross-protection against other non-vaccine types (HPV-35/39/51/52/56/58/59/66/68) was non-significant. Notably, an increase in non-vaccine-preventable-type-related cervical intraepithelial neoplasia of grade 2 (CIN2) or worse was noted in the vaccine group (attributable proportion: 48.40%), compared to 29.52% in the control group ( P = 0.020). No significant differences in incidence or prevalence of non-vaccine-preventable-type infections were found between groups. A significant increase in precancers caused by the non-vaccine-preventable types was demonstrated, despite no evidence of viral replacement 10 years post-vaccination.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,160
Awards: G4632274923, G6481248584
OpenAlex ID: W7083575440