Isolation and characterization of phytoconstituents and exploration of in vitro and in vivo biological activities of Anaxagorea luzonensis A. Gray (Annonaceae)
Year: 2025
Type: article
Abstract: This study aimed to evaluate the α-glucosidase inhibition potential of Prosopis farcta and Rheum ribes. For this purpose, various plant parts—including the root bark, roots, fruits, and leaves of P. farcta, as well as the roots and stalks of R. ribes—were sequentially extracted employing n-hexane, ethyl acetate, and methanol. The α-glucosidase inhibition potential of the extracts was assessed. Subsequently, the phytochemical investigation was carried out on the ethyl acetate extract derived from the root of P. farcta, which exhibited the most pronounced inhibitory effect. This analysis resulted in the isolation and identification of six compounds, including four steroids, one pentacyclic triterpenoid, and one flavonoid. The isolated compounds underwent further evaluation for their α-glucosidase inhibition potential. Among them, daucosterol (3) demonstrated the highest potency, with an IC50 value of 18.6 µM.
Source: OICC Press Journals
Authors: Rahman, Sabiha, -Zohora, Fatema-Tuz, Anjum, Ramisa, Nazmul Hasan, A.H.M., Bhuiyan, Mohiuddin Ahmed, Mahmood Hasan, Choudhury, Shahriar, Mohammad
Institutions: University of Asia Pacific, University of Dhaka
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7083576002
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