Effectiveness of Platelet-Rich Plasma Nasal Packing in Endoscopic Sinus Surgery: A Randomized controlled trial
Year: 2025
Type: article
Abstract: Chronic rhinosinusitis (CRS) is a significant condition impacting millions globally. It is marked by chronic inflammation of the mucosal lining and sinuses. The objective of this study was to assess the impact of platelet-rich plasma packing on mucosal healing and tissue regeneration rates following endoscopic sinus surgery. Methods: This study was an open-label randomized controlled trial conducted at the ENT Department of Alexandria Military Medical Complex, Kobry El Kobba Military Medical Complex, and the ENT Audiology and Phoniatric Hospital at Galaa Military Medical Complex, involving 34 patients with chronic rhinosinusitis scheduled for endoscopic sinus surgery (ESS). Results: The Lund-Mackay CT scores demonstrated no significant disparities across groups preoperatively, indicating equivalent baseline sinus involvement. The SNOT-22 scores for the PRP and control groups commenced at similar moderate symptom levels. The preoperative total Lund-Kennedy scores for both groups were similar (PRP: 7.47 ± 0.51 vs. Control: 7.35 ± 0.49, p = 0.501). The SNOT-22 scores exhibited significant disparities between the PRP and control groups. The PRP group had consistently greater improvement. Within three months, all PRP patients achieved minimum symptom status, in sharp contrast to the control group, which remained in the mild symptom category. The Lund-Kennedy and the Visual Analog Scale (VAS) scores were measured. Conclusion: Platelet-rich plasma nasal packing shows considerable promise in enhancing surgical results for individuals with chronic rhinosinusitis, including improved symptom resolution, diminished pain, and decreased recurrence rates relative to conventional surgical methods.
Source: ARCADEs of MEDICINE
Authors: Ahmed yassin Gohar, Soaad Yehia Mostafa, Wesam Roshdy Mohammed, Ahmed Yehia Abou Elenein, walid abdel fattah sorour, Rania rady kadis, Tahany Mohamed Rabie
Language: English
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7083624546
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