Work

Necrotizing Fasciitis: - a Narrative Review of Epidemiology, Pathogenesis, and Emerging Therapies in Western Uganda

Year: 2025

Type: review

Abstract: Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with high mortality, characterized by fascial necrosis and systemic toxicity. Despite advances in surgical and antimicrobial therapies, NF remains a clinical challenge. This narrative review examines its epidemiology, pathogenesis, and emerging treatments. NF is primarily polymicrobial, with Group A Streptococcus (GAS) and mixed anaerobic-aerobic infections being most common. Pathogenesis involves bacterial virulence, immune evasion, and host susceptibility (e.g., diabetes, immunosuppression). Early surgical debridement and broad-spectrum antibiotics remain the cornerstone of treatment, while emerging therapies—such as immunomodulation (IVIG, hyperbaric oxygen), novel antimicrobials, and bacteriophage therapy—show promise. A multidisciplinary approach is essential, and further trials are needed to validate new treatments.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17221567

Author: Dr. Abdifatah Abdi Ali*1, Prof. Ahmed Kiswezi1, Dr. Abdullahi Osman Abdulle3, Dr. Demoz Abraha2, G.R. Neel2, Prof. Mai Abdalla Ali1

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7083676119

FWCI:

Cites:

Cited by:

Related to: