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Antioxidant, Anti-Inflammatory, And Embryonic Toxicology Evaluation Of Iron Oxide Nanoformulated Sinapic Acid Using Cinnamon

Year: 2024

Type: article

Abstract: Introduction: Iron oxide nanoparticles (Fe₂O₃ NPs) are gaining attention in biomedicine due to their magnetic properties, stability, and low toxicity. This study explored a green synthesis method using sinapic acid and cinnamon extract to produce Fe₂O₃ NPs and evaluated their antioxidant, anti-inflammatory, cytotoxic, and embryonic toxicity profiles. Materials and Methods: Fe₂O₃ NPs were synthesized by mixing iron chloride with cinnamon extract, while sinapic acid was added via sonication. The nanoparticles were characterized using different characterization techniques. Antioxidant and anti-inflammatory activities were assessed through various in vitro assays. Cytotoxicity was tested using brine shrimp, and embryonic toxicity was studied in zebrafish embryos. Results: The green synthesized nanoparticles showed strong anti-inflammatory and antioxidant effects, comparable to standard drugs. Cytotoxicity was low, with high survival in brine shrimp, and over 80% embryo viability was observed at all concentrations. Discussion and Conclusion: The eco-friendly synthesis produced biocompatible Fe₂O₃ NPs with promising therapeutic properties. Their strong bioactivity and low toxicity suggest potential for use in drug delivery and treatments for oxidative stress and inflammation. Further in vivo studies are needed to confirm their clinical relevance.

Source: Journal of Carcinogenesis

DOI: 10.64149/j.carcinog.24.7s.635-643