Characteristics of Patients With Gout Complicated by Kidney and Liver Damage
Year: 2025
Type: article
Abstract: Gout is a chronic metabolic disorder resulting from persistent hyperuricemia and disturbances in purine metabolism. While joint involvement represents the classical clinical manifestation, extra-articular complications—particularly kidney and liver damage—play a decisive role in disease prognosis. This study aimed to characterize the clinical, biochemical, and demographic profiles of patients with gout complicated by renal and hepatic impairment. Analysis demonstrated that renal damage was associated with decreased glomerular filtration rate, urate nephropathy, and higher frequency of hypertension, whereas hepatic involvement was reflected by elevated transaminases, dyslipidemia, and metabolic syndrome components. Patients with combined kidney and liver damage were found to have a more severe disease course, greater inflammatory activity, and an increased burden of comorbidities compared to those without organ involvement. These findings emphasize the importance of early identification of renal and hepatic dysfunction in gout patients, which may contribute to improved risk stratification, individualized therapeutic strategies, and enhanced long-term outcomes.
Authors: Pulatov, U.S., Karimov, A.Kh.
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7083834382
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