Enhanced Perioperative Pain Control in Pediatric Laparoscopic Abdominal Surgery: a Combined Paracetamol and Ibuprofen Approach in Preemptive Multimodal Analgesia
Year: 2025
Type: article
Abstract: The aim of this study was to enhance strategies for managing postoperative pain in pediatric patients undergoing laparoscopic procedures through the implementation of preemptive multimodal analgesia (MMA) based on a combination of paracetamol and ibuprofen. A prospective clinical study included 130 children aged 1 to 17 years, divided into two cohorts: the main group receiving MMA (n=100) and a comparison group receiving opioid-based analgesia (n=30). Efficacy and safety were evaluated based on pain intensity, frequency of adverse events, time to extubation, caregiver satisfaction, and pharmacoeconomic outcomes. The MMA cohort demonstrated a significant reduction in pain intensity, minimal adverse effects, faster recovery of respiratory function, and higher caregiver satisfaction. Additionally, the elimination of opioids contributed to cost-effectiveness. The findings confirm that the proposed approach is reliable, effective, and promising for widespread adoption in pediatric anesthesiology practice.
Author: E.T. Kuralov, E.A. Satvaldieva, B. Khodjiev, A. Abdukadyrov, O.K. Obidov, G.M. Jalilov
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7083836137
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