The Interplay Between Antigen-Induced Mast Cell Activation, Histamine Release and Cyclooxygenase Enzyme Activity in the Pathogenesis of Fever: A Comprehensive Review
Year: 2025
Type: article
Abstract: Fever represents a complex physiological response orchestrated by multiple cellular and molecular mechanisms within the immune system. This comprehensive review examines the intricate relationships between antigen-induced mast cell activation, histamine release, and cyclooxygenase (COX) enzyme activity in fever pathogenesis. Mast cells, strategically positioned throughout tissues, serve as sentinel cells that respond to antigenic stimuli through rapid degranulation and mediator release. The subsequent cascade involves histamine-mediated vascular changes and the activation of COX enzymes, particularly COX-2, leading to prostaglandin E2 (PGE2) synthesis and hypothalamic thermoregulatory responses. Current evidence demonstrates that these pathways are interconnected through complex feedback mechanisms involving inflammatory cytokines, complement activation, and neuroimmune signalling. Understanding these molecular interactions provides critical insights for developing targeted therapeutic interventions. This review synthesizes current literature to elucidate the mechanistic basis of fever development and identifies potential therapeutic targets for clinical management.
Author: Ankita Singh1, Aftab Ansari1, Komal Singh1, Rani Kumari1, Sha Chandankumar Manojkumar1, Navin Singh1, Parinika Kumari1, Mintu Prajapati1, Shaesta Firdous1, Nirjala Kumari1, Priyanjali1, Priya Kumari1, Sudhir Kumar Yadav1, Aman Kumar1, Pushpa Kumari1, Vishal Kumar1, Suman Roy2, Arnab Roy*1
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7084043525
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