Figure 3 from A Phase IB Study of Binimetinib and Palbociclib in Molecularly Selected Advanced Triple-Negative Breast Cancer
Year: 2025
Type: other
Abstract: Correlative studies. A, Dot plot showing the correlation between CDK6 and (B) p-ERK staining (Z-score) and PFS time. The Pearson coefficients were −0.158 (P = 0.472) and 0.143 (P = 0.514). C, Mutational status of HR genes among patients with short (<4 months) or prolonged (>4 months) progression-free interval. Dark color indicates WT status of both alleles; green indicates a heterozygous deleterious mutation, and yellow indicates deleterious alterations in both alleles. D, Heatmap depicting the genes with differential mutational pattern between patients with short or long PFS, listed by their T test score. Darker colors indicate none or lower number of deleterious mutations across their exome, whereas lighter colors indicate increased number of deleterious mutations (up to 5).
Authors: Luis Manso, Rodrigo Sánchez-Bayona, Juan Antonio Guerra, Alfonso Cortés-Salgado, Juan Miguel Cejalvo, José A. García-Saenz, Serafín Morales, Lucía González-Cortijo, Silvana Mourón, María J. Bueno, Leonardo D. Garma, Miguel Quintela-Fandino
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7084112354
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