HUMAN-E: Hypothesis on TGF-β Reduction for Muscle Growth, Immunity, and Healing
Year: 2025
Type: article
Abstract: HUMAN-E is a hypothesis focusing on reducing the activity of TGF-BETA (Transforming Growth Factor-Beta) by around 20–25%. TGF-BETA regulates myostatin, which prevents excessive muscle growth. Lowering TGF-BETA could allow healthier muscle development, stronger bones, improved immunity, and faster wound repair. To balance benefits and risks, the hypothesis suggests combining CRISPR-Cas9 gene editing, calcium and vitamin D supplementation, and tumor-suppressor support. Risks such as cancer and fibrosis are considered, and mitigation strategies are proposed. The project is presented as a scientific proposal, encouraging students, researchers, and professionals to discuss how careful regulation of TGF-β could open new directions in medicine and human enhancement.
Source: Figshare
Author: Vajpayee, Archit
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7084136018
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