Work

Mechanical‐Force‐Driven Radical Cross‐Coupling of Aryl Diazonium Salts with Nitroalkenes

Year: 2025

Type: article

Abstract: An unprecedented mechanical‐force‐induced cross‐coupling of aryl diazonium salts with nitroalkenes has been developed under transition‐metal‐free ball‐milling conditions. This process utilizes readily available sodium chloride (NaCl) as an efficient activator, enabling the cleavage of the CN bond in aryldiazonium salts to generate aryl radicals. These radicals are subsequently trapped by nitroalkenes, leading to the formation of stilbene derivatives. The protocol is notable for its solvent‐free and transition metal‐free synthesis, straightforward operation, broad scope, and exclusive selectivity for the (E)‐configuration of the resulting stilbenes.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70058

Authors: Huiting Yu, Qiuxia Yao, Zihan Wang, Haoran Su, Xiao‐Qiang Hu, Xiaoyun Hu

Institution: South Central Minzu University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities

Awards: G3641153866, G3758437605, G5067689007, G8289973474