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Pulmonary Lymphomatous Granulomatosis: Case report of an uncommon tumor and a brief review of the literature

Year: 2025

Type: article

Abstract: Pulmonary Lymphomatous Granulomatosis (PLYG) is a very rare condition induced by Epstein-Barr virus (EBV) that can present with nonspecific symptoms, leading to diagnostic delays. It has a low frequency and is heterogeneous with respect to clinical, radiological, and pathological features, which makes it a challenging diagnosis and often leads to misdiagnosis with more frequent inflammatory or neoplastic diseases. The case report illustrates the complexity of the path of a patient with high-grade PLYG and the importance of including it in the differential diagnosis of lung masses. Proper diagnosis requires a multidisciplinary approach, combining clinical presentation, high-quality imaging, careful histopathological analysis, and EBV in situ hybridization. The recognition of the various forms of PLYG and its changing grade-related treatment paradigms is the key to prompt intervention and better patient outcomes. As highlighted in this report, collaborative expertise in handling these rare entities is paramount and ultimately leads to increased awareness and improved patient care.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17275720

Authors: Hanna, John, Piris, Kassandra, Jasim, Zainab, Encaoua, Donnah, Jenkins, Ross, Ganga, Shane, Akin, Nadine, Jahoda, Jessica, Aziz, Mohamed

Institutions: Medical University of the Americas, American University of the Caribbean School of Medicine, University of Medicine and Health Sciences, Ross University School of Medicine, St. George's University

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7084760076

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