Molecular Genetic Markers in the Development of Arterial Hypertension
Year: 2025
Type: article
Abstract: Arterial hypertension (AH) has a pronounced genetic determination. A brief historical review of molecular genetic markers of AH is presented: from candidate genes (ACE, AGT, AGTR1, NOS3, etc.) to genome-wide association studies (GWAS) that have identified dozens of replicated small-effect loci (ATP2B1, CACNB2, CYP17A1, NPR3, UMOD, etc.), and to multi-omic approaches (epigenetics, microRNA). Polygenic risk scores are shown to improve prognosis accuracy beyond traditional factors, while pharmacogenetic signals outline personalized therapy choices. Limitations (ethnic tolerance, phenotyping) and prospects for integrating genetics with digital phenotyping to create clinically applicable, ethically verified tools for personalized cardiology are noted.
Author: Tojiboev, T.A.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7084761145
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