MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review
Year: 2025
Type: article
Abstract: This review provides an in-depth analysis of how microRNAs (miRNAs) contribute to the onset, progression, and therapeutic modulation of neurodegenerative diseases (NDDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD).It highlights the emerging importance of miRNA signatures as molecular biomarkers for early detection and personalized interventions, focusing on both molecular mechanisms and clinical applications.Key themes include:Mechanistic insights into miRNA dysregulation in neuronal pathways, synaptic signaling, and neuroinflammatory cascades.Overview of modern miRNA detection platforms, including digital PCR, nanoparticle-based assays, and biosensor technologies.Evaluation of miRNA-based therapeutics, encompassing antisense inhibitors, mimics, and RNA delivery systems tailored to overcome the blood–brain barrier (BBB).Discussion on standardization challenges, computational modeling, and translational strategies needed to move miRNA research from laboratory discovery to clinical reality.By integrating findings from molecular neuroscience, bioinformatics, and nanobiotechnology, this article underscores how miRNA-centered approaches are shaping the future of neurodiagnostics and RNA therapeutics.📖 Read the Full Reviews:Azam, H.M.H. et al. MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies—advances and challenges. Neurological Sciences (2025). https://doi.org/10.1007/s10072-025-08419-wAzam, H.M.H. et al. MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review. Frontiers in Molecular Neuroscience (2024). https://doi.org/10.3389/fnmol.2024.1386735#miRNA #Neurodegeneration #Neuroscience #Neurobiology #RNAResearch #Alzheimers #Parkinsons #ALS #Huntingtons #Biotechnology #PrecisionMedicine #MolecularDiagnostics #Biosensors #Bioinformatics #NeuroDiagnostics #TranslationalMedicine #FrontiersJournals #SpringerNature #ResearchImpact #ScienceCommunicatio
Source: Figshare
Author: Azam, Hafiz Muhammad Husnain
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7085475218
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