Work

Role of sarA and agr in Insulin Modulation of Staphylococcus aureus Biofilm Formation

Year: 2025

Type: article

Abstract: The focus of this study is to determine whether insulin, quorum signaling and biofilm formation are under regulation of agr and sarA regulation. Deletion strains agr-, sarA -, and agr-sarA- as well as their parent strain 8325-4 were tested with and without glucose (0.1% and 0.2%) and/or physiologic levels of insulin (2µU/mL, 20µU/mL, and 200µU/mL). In the absence of sarA and agr, there was a marked suppression of biofilm levels in the presence of insulin, indicating that insulin modulation of biofilm formation appears to be regulated, in part, by sarA and agr.

Source: World Journal of Biology Pharmacy and Health Sciences

DOI: 10.30574/wjbphs.2025.24.1.0860

Authors: Balbina J. Plotkin, Monika I. Konaklieva, Ira Sigar

Institutions: Midwestern University, American University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: Midwestern University

OpenAlex ID: W7085648443