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Prevalence of Vitamin B12 Deficiency in Patients with Depressive Symptoms: Clinical and Biochemical Correlations

Year: 2025

Type: article

Abstract: Objective: To evaluate the prevalence of vitamin B12 deficiency in patients presenting with depressive symptoms and to explore its biochemical and clinical implications. Methods: Observational study assessing serum vitamin B12, folate, ferritin, thyroid function, and homocysteine in patients with depressive symptoms. Results: Vitamin B12 deficiency was identified in a significant proportion of patients, with associated elevations in homocysteine and frequent comorbid deficiencies in ferritin and thyroid dysfunction. Conclusion: Vitamin B12 deficiency is a common yet underrecognized contributor to depressive symptomatology, and routine screening should be integrated into psychiatric evaluations.

Source: International Journal of Science and Research Archive

DOI: 10.5281/zenodo.17311874

Authors: Lozano, Roberto, Bona, Carina

Institutions: Hospital Clínico Universitario Lozano Blesa, Servicio Aragonés de Salud

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7087522830

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