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The Polyclonal Hypothesis Of Cancer Origin: From Field Injury to Functional Monoclonality in Cancer Origin

Year: 2025

Type: article

Abstract: A paradigm-challenging concept paper proposing that cancer often originates from multiple independently transformed clones within a shared tissue field, with clonal dominance emerging through ecological selection rather than single-cell origin.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17329552

Author: Ouma, Okoth Regan

Institution: University of Nairobi

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7088019693

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