Year: 2025
Type: article
Abstract: Refractory type 2 diabetes mellitus (T2DM) remains a significant therapeutic challenge, as many patients continue to exhibit inadequate glycemic control despite optimal pharmacologic management. Duodenal mucosal resurfacing (DMR) is a novel endoscopic technique designed to rejuvenate the duodenal lining and enhance insulin sensitivity, leading to better glycaemic regulation. This case illustrates a 54-year-old male with a 12-year history of T2DM who remained poorly controlled despite multiple oral agents and high-dose insulin. He underwent DMR resulting in significant improvements in glycemic parameters. The patient’s HbA1c decreased from 10.2% to 7.1% over a three-month period, with concomitant reductions in fasting glucose levels and insulin requirements. This case demonstrates that DMR may serve as a safe and beneficial adjunctive approach for individuals with treatment-resistant type 2 diabetes when conventional management proves insufficient.
Source: Academic Medicine & Surgery
DOI: 10.62186/001c.145731
Authors: Amjad Rami, Zainab Alsayes, Khaled Kettaneh, Rajaa Mohammad, Seba Obeidat, Sereen Draghmeh
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7088324708