Ectopic parathyroid hormone-producing cervical cancer requiring hemodialysis owing to acute hypercalcemia: a case report
Year: 2025
Type: article
Abstract: Background Parathyroid hormone-related protein (PTHrP) is often the underlying causeof malignancies complicated by hypercalcemia. However, in rare instances, ectopic production of parathyroid hormone (PTH) by tumors can be responsible, with hypercalcemia rarely reported. Case presentation We report the case of a 55-year-old female who was admitted with general fatigue and developed acute consciousness disturbance with a rapid rise in intact serum PTH to 12,258 pg/mL and corrected calcium to 14.3 mg/dL. Despite zoledronic acid administration, hypercalcemia remained refractory and required hemodialysis. Calcium levels and consciousness improved; however, her overall condition deteriorated, and she eventually succumbed to progressive hepatic failure. Postmortem examination revealed multiple metastases from ectopic PTH-producing cervical cancer. Conclusions Although ectopic PTH-producing malignancies are extremely rare, ectopic PTH-producing tumors should be considered when unexplained hypercalcemia with negative PTHrP is encountered. Prompt initiation of hemodialysis is warranted in patients with severe symptomatichypercalcemia.
Source: Renal Replacement Therapy
Authors: Yusuke Ushio, Yosuke Iwatani, Mayuko Suyama, Ayano Tanaka, Mihoko Mizutani, Momoko Seki, Yuka Shimizu, Koichiro Shiogai, Nagisa Ando, Nozomi Sato, Kouta Higashi, Masahide Tazawa, Kana Nomura, Haruka Kato, Anna Nakai, Hitoko Sumori, Shiho Makabe, Shizuka Kobayashi, Yuki Kawaguchi, Shun Manabe, Hiroshi Kataoka, Naoko Ito, Sekiko Taneda, Tomoko Yamamoto, Kosaku Nitta, Junichi Hoshino
Institution: Tokyo Women's Medical University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7089623116