Front Cover: Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1 (Chem. Eur. J. 56/2024)
Year: 2024
Type: paratext
Abstract: Dancing in the dark: Supramolecular binding units mediate specific docking of novel linker systems to lock the ligands’ jaws on the target protease Taspase1. Molecular tweezers were connected by aggregation-induced emission (AIE) functionalities to generate spider-like inhibitors lighting up upon protein binding. Utilizing a calix[4]arene backbone resulted in a scorpion-like double pincer ligand with even superior binding and enzyme inhibition properties. More information can be found in the Research Article by J. Voskuhl, T. Schrader, S. K. Knauer and co-workers (DOI: 10.1002/chem.202401542).
Source: Chemistry - A European Journal
Authors: Katrin Hommel, Alisa‐Maite A. Kauth, Abbna Kirupakaran, Sebastian Theisen, Matthias Hayduk, Felix C. Niemeyer, Christine Beuck, Reza Zadmard, Peter Bayer, Bart Jan Ravoo, Jens Voskuhl, Thomas Schrader, Shirley K. Knauer
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7089754290
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