Study on a growth promoting effect and mechanism of the extract of stem and leaf from Atractylodes lancea DC. on nile tilapia
Year: 2025
Type: article
Abstract: Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated Atractylodes lancea DC. extract (ALE) on Lactiplantibacillus plantarum growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE’s effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE’s potential for sustainable aquaculture.
Source: Figshare
Authors: Tian, Wei, Wang, Ziying, Shi, Dongdong, Huang, Zhiwei, Liu, Yuefei, Li, Xiumei
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
SDG: Zero hunger
Open Access status: green
OpenAlex ID: W7090372115
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