Work

Designing Anti-Microbial Peptides

Year: 2025

Type: article

Abstract: Escherichia coli antibiotic resistance is a severe global health problem. Antimicrobial peptides (AMPs) may be a potential solution. This research involved amino acid sequence optimization of a short 10-residue peptide (HKTDSFVGLM, probability 0.6325) using CAMPr3 and AlphaFold and ToxicPred3 to determine the resultant 13-residue peptide (HKRKKWWALLAKK, probability 0.8541). The resultant peptide possessed higher predicted antimicrobial activity, ability to form an amphipathic helix, and non-toxic characteristics than the original peptide, thus illustrating the validity of computational design of peptides in the pursuit of a novel therapeutic.

DOI: 10.13021/mars/15107

Author: Adi, Devya

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7090934564

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