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Analysis of the role and significance of drugs acting on cholinergic receptors in medical practice

Year: 2025

Type: article

Abstract: All of the body's organs and tissues have muscarinic acetylcholine (ACh) receptors, commonly referred to as M receptors. These receptors primarily function in cholinergic nerve conduction. Although there are five distinct subtypes of muscarinic ACh receptors, it is still unclear how each of them affects cardiac function pharmacologically. Muscarinic ACh receptors may have an impact on functional myocardial disorders and myocardial traumas, including arrhythmia, myocardial ischemia, myocarditis, and myocardial fibrosis. In order to develop better strategies and provide references for further revealing and clarifying the signal transduction and mechanisms of muscarinic ACh receptors in cardiomyocytes, as well as to identify potential myocardial protective drugs that act on muscarinic ACh receptors, this article reviews the research progress on the regulation of myocardial function by muscarinic ACh receptors and related diseases.

Source: Eurasian Journal of Medical and Natural Sciences

DOI: 10.70413/ejmns-v05-i10-s10784

Authors: Sokhib Rashidov, Nigora Yakubova, Madina Shakhmurova

Institutions: Tashkent State University of Law, Tashkent Pediatric Medical Institute, Tashkent State University of Economics

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7091283731

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