Work

Elucidating mechanisms that enhance metastatic phenotypes through pharmacological ascorbate and fluid shear stress resistance

Year: 2025

Type: article

Abstract: The motivation for initiating Chapter 2 was due to the clinical outcomes in the Phase I and II PDAC pharmacological ascorbate (P-AscH) trials. Patients treated with intravenous injections of P-AscH in combination with standard-of-care therapy demonstrated a significant increase in overall survival and progression free survival. Despite these encouraging results, approximately 30% of patients did not respond to this treatment regimen. To elucidate mechanisms of resistance to P-AscH, I developed two pancreatic cancer cell lines. Despite originating from the same cancer type, the two P-AscH resistant (AR) cell lines developed unique mechanisms to tolerate treatments to P-AscH.

Source: Iowa Research Online (The University of Iowa)

DOI: 10.25820/etd.008072

Author: Pope, Amanda Nicole

Language: English

Topic: Vitamin C and Antioxidants Research

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7091540067

FWCI:

Cites:

Cited by:

Related to: