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Genetic Mutations in Prostate Cancer: Insights and Implications

Year: 2025

Type: article

Abstract: This review article aims to provide a comprehensive overview of genetic mutations and alterations in prostate cancer, highlighting their roles in disease development and progression. The scope of the review encompasses common genetic mutations, such as those in the PTEN and TP53 genes, as well as structural alterations like the TMPRSS2-ERG fusion. It also discusses the impact of these genetic changes on cellular functions, including cell cycle regulation and signaling pathways. Major findings indicate that genetic mutations contribute to the uncontrolled proliferation of prostate cells and influence treatment responses, emphasizing the importance of molecular profiling in guiding personalized therapy. Additionally, the review explores the significance of the tumor microenvironment and epigenetic modifications in prostate cancer progression. The insights gained from this review underscore the necessity for ongoing research into genetic alterations to improve diagnostic methods and therapeutic strategies, ultimately enhancing patient outcomes.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17355887

Authors: Okorochi, Chinenye Mary, Akinbo, Frederick Olusegun, Eze, Gerald Ikechi, Olukoya, Kehinde Elizabeth, Okorochi, Enoch Chibuike, Obiozor, Austin Ifeanyi, Ibe, Uzochukwu Chimdindu, Iyalla, Simon Enenche, Ukachukwu, Macpherson Ifeanyi

Institutions: Babcock University, University of Benin, Joseph Ayo Babalola University, Imo State University, Federal Teaching Hospital Abakaliki, University of Jos, David Umahi Federal University of Health Sciences Uburu

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7091570605

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