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Front Cover: Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle‐Based Delivery (Chem. Rec. 10/2025)

Year: 2025

Type: paratext

Abstract: The cover illustrates G-quadruplex-forming aptamers as therapeutic oligonucleotides for neurodegenerative diseases. Their unique secondary structures confer high target specificity, while clay-based nanocarriers, including halloysite nanotubes and montmorillonite, are depicted as stabilizing and delivery platforms. This combination provides exciting opportunities to enhance nuclease resistance, bioavailability, and targeted transport across biological barriers. More details can be found in the Review by Bruno Pagano and co-workers (DOI: 10.1002/tcr.202500126).

Source: The Chemical Record

DOI: 10.1002/tcr.70050

Authors: Valentina Arciuolo, Federica D’Aria, Maria Rita Caruso, Martina Maria Calvino, Jussara Amato, Giuseppe Lazzara, Stefana Milioto, Concetta Giancola, Giuseppe Cavallaro, Bruno Pagano

Institutions: University of Naples Federico II, University of Palermo

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7091636525

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