Formulation and Evaluation of Mucoadhesive Buccal Patch of Celecoxib
Year: 2025
Type: article
Abstract: This study focuses on the formulation and evaluation of mucoadhesive buccal patches containing celecoxib, a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain and inflammation. Due to its poor water solubility and significant first-pass metabolism, buccal drug delivery offers a promising alternative to enhance its bioavailability and therapeutic effect. Patches were prepared by the solvent casting method using hydroxypropyl methylcellulose (HPMC) in different ratios as the primary polymer. Polyethylene glycol 400 (PEG 400) was incorporated as a plasticizer to improve film flexibility, while Tween 80 was used as a solubilizer to aid in drug dispersion. The formulations were evaluated for various parameters such as thickness, weight uniformity, surface pH, folding endurance, drug content, tensile strength, swelling index, and in vitro drug release. FTIR spectroscopy was performed to assess drug–polymer compatibility, confirming the absence of significant interactions. The optimized formulation showed uniform physical properties, good folding endurance, satisfactory drug content, and excellent mucoadhesive strength. It provided a sustained release of celecoxib over a period of 6 hours, making it suitable for prolonged retention and controlled delivery via the buccal route. Overall, the developed mucoadhesive buccal patch of celecoxib presents a patient-friendly and effective alternative to conventional oral dosage forms, especially in managing localized dental pain and inflammation.
Author: M Sohil M Shabbir1*, Shaikh Imran Kalam2, Dr. G. J. Khan3
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7092211203
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