The dataset of Prevotella intermedia Culture Supernatant Impairs Alveolar Macrophage Function and Promotes Mycobacterium avium Persistence
Year: 2025
Type: article
Abstract: We investigated the efficacy of Prevotella intermedia culture supernatant (P. int. sup.) on alveolar macrophage-like cells (AMLCs) differentiated from bone marrow cells in mice. Figure 1. P. int. sup. augments phagocytic function and impairs bactericidal ability. Figure 2. P. int. sup. increases the intracellular burden of Mycobacterium avium and suppresses bactericidal gene expression in AMLCs. Figure 3. Bulk RNA sequencing shows downregulation of mRNA expression in Mycobacterium avium-infected AMLCs. Figure 4. P. int. sup. downregulates type I interferon signaling and anti-mycobacterial genes while upregulating IL-6 and MHC class II expression in Mycobacterium avium-infected AMLCs. Figure 5. SLPI treatment reduces the number of Mycobacterium avium.
Authors: Koki, Fukushima, Iwanaga, Naoki, Takeda, Kazuaki, Hirayama, Tatsuro, Yoshida, Masataka, Ide, Shotaro, Tashiro, Masato, Takazono, Takahiro, Kosai, Kosuke, Sakamoto, Noriho, Izumikawa, Koichi, Naito, Mariko, Yanagihara, Katsunori, Mukae, Hiroshi
Institutions: Nagasaki University Hospital, Nagasaki University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7092361575