Modeling of the excitation propagation of the human heart
Year: 2025
Type: article
Abstract: This study presents a computational model for simulating excitation propagation in the human heart using a Monodomain reaction-diffusion framework coupled with the Aliev-Panfilov model for the ionic reaction term. The objective is to address the Forward Problem in cardiac electrophysiology by modeling how electrical activation initiated at the conduction system propagates through the myocardium. Cellular and tissue-level dynamics are integrated using diffusion tensor imaging (DTI)-derived anisotropy and conduction network structures. Two conduction system models are evaluated, one based on trabecular muscle anatomy and another using diffusion volume (DV) metrics. Numerical simulations demonstrate activation isochrones comparable to experimental data from Durrer et al., highlighting the model's validity in capturing realistic ventricular excitation patterns. Visualization was achieved using OpenGL-based C/C++ simulations.
Author: ELAFF, Ihab
Institution: Qatar University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7092369193
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