Year: 2025
Type: article
Abstract: As the world’s most trafficked mammal, the trafficked pangolins, from which multiple microorganisms are identified, may be more prone to diseases by various zoonotic agents and also accelerate their spread. Herein, we collected internal organ and/or fecal samples from 15 trafficked pangolins rescued at the Jinhua Wildlife Rescue Station in Zhejiang province of China. Through meta-transcriptomics and PCR, pestivirus, canine parvovirus 2 (CPV-2), human parainfluenza virus 2 (HPIV2) and Pseudomonas aeruginosa at high abundances were identified in three dead pangolins, while no potential pathogens were found in the remaining 12 alive pangolins. Of three dead pangolins, Pujiang-Pangolin-2 and Pujiang-Pangolin-3 were co-infected by four and two agents respectively, which led to more pronounced pathological changes in them than in Qingtian-Pangolin-1, from which only CPV-2 was detected. In particular, Pujiang-Pangolin-2 had an extremely high abundance of CPV-2 and P. aeruginosa in lung and spleen, and also exhibited severe pathologic changes, while Pujiang-Pangolin-3 had a higher abundance of pestivirus and exhibited more severe hemorrhage in its internal organs. Notably, the viral agents identified herein were more closely related to the pestiviruses harbored by Manis javanica, CPV-2 sampled from dogs in Vietnam, and HPIV2 sampled from humans in Netherlands, respectively, while P. aeruginosa showed a closer evolutionary relationship to the bacteria sampled from humans in and outside of China. In sum, combing with previous studies, these data suggest that the trafficked pangolins are prone to various infections and also resulted in the spread of zoonotic agents.
Source: 动物学研究
Authors: Lin Xian-Dan, 复旦大学生命科学学院复杂性状的遗传调控全国重点实验室, 人类表型组研究院, 粤港澳大湾区精准医学研究院(广州), 上海 200438, 中国, Quan Shuo-Wei, Lv Jia-Xin, Liu Ming-Qiu, Pei Yuan-Yuan, Liu Xiang, Luo Xiu-Qi, Meng Hai-Feng, Chen Yan-Mei, Zhang Yong-Zhen, 温州市疾病预防控制中心(温州市卫生监督所), 浙江 温州 325035, 中国, 金华市野生动物救护中心, 浙江 金华 321000, 中国, Jinhua Wildlife Rescue Station, Jinhua, Zhejiang 321000, China
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7093320083