Work

OR33-05 10 Year Trend in Outcomes of Acute Myocardial Infarction Hospitalization in Patients With Type 1 Diabetes

Year: 2025

Type: article

Abstract: Disclosure: J. Bello: None. E. Erhus: None. S. Saha: None. J. Ibarra: None. S.R. Nandyal: None. A. Ilelaboye: None. K. Okonkwo: None. Myocardial infarction (MI) remains the leading cause of death in patients with diabetes mellitus (DM). There have been several advances in the management of type 1 DM including use of insulin pump and continuous glucose monitors but little is known about how this has affected myocardial infarction incidence and outcomes over the years. Although type 1 DM is unique is several ways (pathophysiology, age of onset and management), there is limited data on the impact of type 1 diabetes mellitus (T1DM) on outcomes following acute myocardial infarction (AMI). Most studies to date have investigated the overall diabetic population.METHODOLOGYThis was a retrospective longitudinal study using data from the Healthcare Cost and Utilization Project National Inpatient Sample from 2012 to 2021. Patients hospitalized with a primary diagnosis of acute myocardial infarction and a secondary diagnosis of type 1 DM were identified using ICD 9 and 10 codes. Trends in outcomes were assessed, stratified by sociodemographic variables. The Primary outcome was mortality. Secondary outcomes were the length of hospital stay and total hospital charge RESULTS AND DISCUSSIONThe number of patients hospitalized with acute MI who also had type 1 DM showed a steady increase from 5,175 in 2013 to a peak of 6,384 in 2018 at followed by a downward trend to 5,529 in 2021. About 1% of patients hospitalized with AMI had type 1 DM and this number remained stable. The prevalence of myocardial infarction (acute or previous MI) in patients with type 1 DM however showed a consistent decrease from 48.7% in 2012 to 34% in 2021.The mortality rate declined from 6.9% in 2013 to 3.4% in 2019 followed by a sharp increase to 5.5% in 2021. The odds of mortality increased by 1% each year among males and Caucasians, and by 2.87% each year in elderly patients and this was statistically significant after adjusting for confounders (P < 0.001). The length of stay remained stable during the study period however, the total hospital charge progressively increased after adjusting for inflation and other confounders.This steady increase in mortality in Caucasians and in males calls for special attention to glycemic control and control of cardiovascular risk factors in these populations. The increased mortality rate in 2020 is likely attributable to the effect of the COVID 19 pandemic. Presentation: Monday, July 14, 2025

Source: Journal of the Endocrine Society

DOI: 10.1210/jendso/bvaf149.1035