Work

Role ofNramp1Deletion inChlamydiaInfection in Mice

Year: 2000

Type: article

Abstract: Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachomatis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Furthermore, the two groups of mice were shown to be similarly susceptible to an intranasal infection with these microorganisms. In conclusion, the Nramp1 gene does not appear to play a major role in the regulation of the susceptibility of mice to a chlamydial infection.

Source: Infection and Immunity

DOI: 10.1128/iai.68.8.4831-4833.2000

Authors: Sukumar Pal, Ellena M. Peterson, Luis M. de la Maza

Institution: University of California, Irvine

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases