Year: 2021
Type: article
Abstract: There are over 100 trillion microbial cells in the human, mostly in the large intestine, and all of these organisms are gut microbiota.The gut microbiota plays an important role in gastrointestinal mucosal permeability, the secretion of intestinal hormone and fermentation and absorption of dietary polysaccharides.In addition, gut microbiota play an important role in the host's immune system, regulation of inflammatory processes and energy production from foods.Symbiotic bacteria and pathogenic bacteria are in equilibrium in the gut microbiota of healthy organisms.The imbalance of gut microbiota has been associated with increased immunological and metabolic disorders in both animals and humans.Diabetes mellitus is a chronic disease characterized by hyperglycemia.The incidence of diabetes mellitus has increased rapidly throughout the world in the last twenty-years and has become an important public health problem.Besides genetic and environmental factors, diabetes mellitus has also been associated with gut microbiota.Many studies have shown that diabetic patients have moderate dysbiosis in gut microbiota.However, the relationship between diabetes development and gut microbiota composition remains unclear in humans.In this review, we aimed to focus on the relationship between gut microbiota and diabetes mellitus, and to discuss the results of modulation gut microbiota therapeutically in the treatment of diabetes mellitus.
Authors: Zinnet Şevval AKSOYALP, Cahit NACİTARHAN
Institutions: Akdeniz University, Izmir Kâtip Çelebi University
Language: Turkish
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3165301233